Evaluation of Relationship between Occurrence of Liver Cancer and Methylation of Fragile Histidine Triad (FHIT) and P16 Genes
نویسندگان
چکیده
منابع مشابه
FHIT (fragile histidine triad)
Fhit protein is a tumor suppressor with reduced or no expression in many types of cancer. Fhit expression is more frequently lost in cancers of individuals with familial mutations causing deficiency in DNA repair genes such as BRCA1 and BRCA2 and MSH2. In vitro Fhit acts as a hydrolase that cleaves diadenosine triphosphate (Ap3A) to ADP and AMP. The Fhit-Ap3A enzyme-substrate complex appears to...
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ژورنال
عنوان ژورنال: Medical Science Monitor
سال: 2019
ISSN: 1643-3750
DOI: 10.12659/msm.912315